DISORDERS OF FAT (LIPID) METABOLISM, TSV. DYSLIPOPROTEINAEMIA, IS ONE OF THE MOST IMPORTANT RISK FACTORS FOR CARDIOVASCULAR DISEASE, WHICH CAN RESULT IN ACUTE MYOCARDIAL INFARCTION, ISCHAEMIC HEART DISEASE OR STROKE.
DISORDERS OF FAT/CHOLESTEROL METABOLISM
Disorders of fat (lipid) metabolism, called dyslipoproteinaemia, are one of the highest risk factors for cardiovascular disease, which can result in acute myocardial infarction, coronary heart disease or stroke. Lipids are a very diverse group of water-insoluble substances. In blood plasma, lipids are found in the form of fatty acids, phospholipids, triglycerides and cholesterol. Since they are not soluble in the aqueous environment of the blood, their transport is provided by lipoprotein complexes in which they are bound to proteins. From the point of view of our civilisation, it is mainly the cholesterol and triglyceride indicators that will be important to us.
Cholesterol is associated with a number of dangerous diseases. However, many people do not know that cholesterol is a natural part of the cells of the human body and is essential for life. Concerns about its presence are not misplaced because it performs a number of important functions. It forms the basis of all cell membranes, is abundant in the nervous system, the brain, the myelin sheaths of nerves, and is found in the liver and kidneys. It is a building block for the synthesis of sex and adrenal hormones, the formation of bile and is essential for the synthesis of vitamin D. On the other hand, high levels are an important risk factor for heart and blood vessel disease. Cholesterol found in the human body comes from two sources. The external source of cholesterol is food, which accounts for 20-40% of total cholesterol. Most of it is found in animal fats, sausages, tripe, egg yolk and fatty dairy products. The internal source accounts for 60-80 % of its own endogenous cholesterol production, which is mainly through the liver, the intestines and the adrenal glands. The elimination of cholesterol from the body is mainly by the liver. Here it is used for the synthesis of bile acids or excreted directly into the bile.
Types of cholesterol
According to its structure, cholesterol can be divided into:
- VLDL-very low-density lipoprotein cholesterol
- harmful LDL-cholesterol with a tendency to deposit in the blood vessel walls, creating the conditions for atherosclerosis
- good, beneficial HDL-cholesterol, which promotes the transport of cholesterol from the bloodstream to the liver, where it is broken down
Triglycerides are fatty substances composed of glycerol and higher fatty acids. These fats are taken up exclusively through food and serve as a source of energy in the body.
Total cholesterol up to 5.0 mmol/l
LDL-cholesterol up to 2,5 mmol/l
Triglycerides up to 1.7 mmol/l
HDL-cholesterol over 1.0 mmol/l
Types of dyslipidaemias
In clinical practice, the 1992 European Society of Atherosclerosis classification is widely used and is useful in therapeutic considerations:
1. Isolated hypercholesterolaemia - elevated cholesterol concentration with normal triglyceride levels.
2. Mixed hyperlipidaemia - simultaneous increase in total cholesterol and triglycerides
3. Isolated hypertriglyceridemia - an increase in triglyceride concentration with normal total cholesterol concentration
What are the causes of elevated blood lipid levels?
1. Primary - they are genetically determined and respond less well to treatment
2. Secondary, which can be caused by:
- poor eating habits
- unhealthy lifestyle, lack of exercise, overweight
- liver disease, pancreatic disease, reduced thyroid function or pregnancy
- medications - hormonal contraceptives, corticosteroids, drainage drugs, some drugs for the treatment of hypertension
- elevated levels of homocysteine, produced by the metabolism of the amino acid methionine, found mainly in animal proteins (this is a more recent theory)
Classical treatment of fat/cholesterol metabolism disorders
The therapy consists of a complex of dietary measures with the basic principle of reducing the intake of cholesterol and animal fats on the one hand and increasing the intake of fruit, vegetables and fibre on the other. Regimen measures include weight reduction, increased physical activity, non-smoking. Pharmacotherapy is based on the administration of drugs - so-called hypolipidemics, most often from the group of statins and fibrates. Treatment of concomitant diseases such as diabetes, obesity and high blood pressure is also an integral part of the treatment.
Fat/cholesterol metabolism disorders and Energy preparations
Energy products represent a significant benefit in preventing and influencing complications of advanced disease. These modern bioinformation products are an alternative that offers a holistic, natural and gentle approach.
Main products
- The first step - REGALEN - potentiates liver activity in cholesterol metabolism. Dosage: 5-7 drops 3 times a day.
- Second step - KOROLEN - it is a basic preparation for harmonization and detoxification of the cardiovascular system. Dosage: 5-7 drops 3 times a day.
- VITAMARIN - the effects of omega-3 fatty acids on lowering cholesterol and triglyceride levels have been demonstrated in numerous clinical studies. Dosage: 1 capsule 3 times a day after meals.
Complementary products
- CELITIN - lowers cholesterol levels by the content of lecithin present. Improves the elasticity of blood vessels. Dosage.
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PROBIOSAN INOVUM - the latest research has demonstrated the ability of probiotic bacteria to convert cholesterol into ineffective coprostanol, thereby lowering total and LDL-cholesterol levels in the blood. Dosage: 1 capsule 3 times a day.
- FLAVOCEL - the main benefit is its antioxidant abilities. It prevents damage to HDL-cholesterol by oxygen free radicals. Dosage: 1 tablet 2 times a day.
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ORGANIC CHLORELLA - reduces the production of own, endogenous cholesterol in the liver, promotes the excretion of cholesterol in the stool. Dosage: 2 tablets 3 times a day.
Complementary preparations should be alternated and can be combined with each other.
The dosage of the preparations is indicative and must be adjusted according to the state of the disease and the age and reactivity of the patient. In general, use low doses for chronic long-term diseases and older age groups, and higher doses for young individuals and acute conditions.
Brochure Cholesterol prepared by MUDr. Jiří Hanzel